Potensi Ekstrak Jagung Sebagai Pencegahan Katarak

  • Sri Mariati RSUD dr. Soetomo Trenggalek
  • Danang Diasrullah Bhekti Universitas Muhammadiyah Malang
  • Alfa Sylvestris Universitas Muhammadiyah Malang
  • Risma Karlina Prabawati Universitas Muhammadiyah Malang
Keywords: Katarak, Senilis, Ekstrak Jagung, Lutein, Zeaxanthin


Senile cataract is a cataract caused by the aging process that begins at the age of more than 50 years caused by free radicals, such as reactive oxygen species (ROS), formed as a result of external and internal exposure. Utilization of the potential of this corn extract has advantages with minimal side effects by utilizing corn extract, namely lutein zeaxanthin as a prevention of senile cataract. The main purpose of this literature review is to determine the potential of corn extract (Zea mays sp.) on the prevention of senile cataract. This research is literature study using national and international journals with the Scopus index published in 2016-2021 as well as literature books. Journals were obtained from search engines Google Scholar and Pubmed NCBI. Data and information obtained to support the research objectives. Cataracts are caused by Reactive Oxidative Stress (ROS). Zeaxanthin compounds work with their antioxidant properties by activating the synthesis of glutathione (GSH) in human RPE cells. Zeaxanthin increases the translocation of Nuclear receptor factor 2(Nrf2) by reducing the binding activity of Nrf2 to Kelch like ECH-Aasosiated protein 1 (Keapl1) in ARPE-19 cells. Furthermore, inhibition of GSH synthesis by buthionine suphoximine abolished the protective effect of zeaxanthin against oxidative stress-induced reduction of mitochondrial membrane potential and cell apoptosis in ARPE-19 cells thereby helping to prevent the formation of oxidative stress causing senile cataract. Corn extract (Zea mays sp.) has potential in the prevention of senile cataract because it has good antioxidant activity


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Suryathi NMA. Juliari IGAM. Andayani A. Jayanegara IWG. Ratnasari N. Putrawati AAM. Barriers of Cataract Surgery in South Timor Tengah, East Nusa Tenggara-Indonesia. The Open Public Health Journal. 2019; 12(1): 7–10. Available from: https://doi.org/10.2174/1874944501912010007

Yu HJ. Kuo MT. Wu PC. Clinical characteristics of presenile cataract: Change over 10 years in southern Taiwan. BioMed Research International. 2021. Available from: https://doi.org/10.1155/2021/9385293

Kementan RI. Katarak penyebab kebutaan terbanyak. 2019. Available from: https://www.kemkes.go.id/article/view/20100600004/katarak-penyebab-terbanyak-kebutaan.html

Scripsema NK. Hu D. Rosen RB. The Clinical Management of Eye Disease. Journal of Ophthalmology. 2015;

Baseggio M. Murray M. Magallanes-Lundback M. Kaczmar N. Chamness J. Buckler ES. et al. (2020). Natural variation for carotenoids in fresh kernels is controlled by uncommon variants in sweet corn. Plant Genome. 2020; 13(1): 1–19. Available from: https://doi.org/10.1002/tpg2.20008

Perrone S. Tei M. Longini M. Buonocore G. The Multiple Facets of Lutein: A Call for Further Investigation in the Perinatal Period. Oxidative Medicine and Cellular Longevity. 2016. Available from: https://doi.org/10.1155/2016/5381540

Song J. Li D. Liu, N. Liu C. He M. Zhang Y. Carotenoid composition and changes in sweet and field corn (Zea mays) during kernel development. Cereal Chemistry. 2016; 93(4): 409–413. Available from: https://doi.org/10.1094/CCHEM-11-15-0230-N

Sukto S. Lomthaisong K. Sanitchon J. Chankaew S. Scott MP. Lübberstedt T. Suriharn B.. Zeaxanthin of Yellow Small-Ear Waxy Corn Germplasm. International Journal of Agronomy. Available from https://doi.org/10.1155/2020/8818768

Roberts J. E. Dennison J. The Photobiology of Lutein and Zeaxanthin in the Eye. Journal of Ophthalmology. 2015. Available from: https://doi.org/10.1155/2015/687173

Jia YP. Sun L. Yu HS. Liang LP. Li W. Ding H. et al. The pharmacological effects of lutein and zeaxanthin on visual disorders and cognition diseases. Molecules. 2017; 22(4): 1–22. Available from: https://doi.org/10.3390/molecules22040610

Hirdyani H. Lutein – the Less Explored Carotenoid. World Journal of Pharmaceutical Research. 2017 Jun;528–553. Available from: https://doi.org/10.20959/wjpr20176-8671

Jeon S. Neuringer M. Kuchan MJ. Erdman J W. Relationships of carotenoid-related gene expression and serum cholesterol and lipoprotein levels to retina and brain lutein deposition in infant rhesus macaques following 6 months of breastfeeding or formula feeding. Archives of Biochemistry and Biophysics. 2018; 654: 97–104. Available from: https://doi.org/10.1016/j.abb.2018.07.004

Yang J. Li D. Zhang Y. Zhang L. Liao Z. Aihemaitijiang SMY. et al. Lutein protected the retina from light induced retinal damage by inhibiting increasing oxidative stress and inflammation. Journal of Functional Foods. 2020; 73: 104107. Avalailable from: https://doi.org/10.1016/j.jff.2020.104107

Li LH. Lee JCY. Leung HH. Lam WC. Fu Z. Lo ACY. Lutein supplementation for eye diseases. Nutrients. 2020; 12(6): 1–27. Available from: https://doi.org/10.3390/nu12061721

Qin L. Tao Y. Wang L. Chen H. Liu Y. Huang YF. Hydrogen- rich saline as an innovative therapy for cataract: A hypothesis. Medical Science Monitor. 2016; 22: 3191–319. Available from: https://doi.org/10.12659/MSM.899807

Dogru M. Kojima T. Imsek C. TsubotavxK. Potential role of oxidative stress in ocular surface inflammation and dry eye disease. Investigative Ophthalmology and Visual Science; 59(14 Special Issue): DES163–DES168. Available from: https://doi.org/10.1167/iovs.17-23402

Milani A. Basirnejad M. Shahbazi S. Bolhassani A. Carotenoids: biochemistry, pharmacology and treatment. British Journal of Pharmacology. 2017; 174(11): 1290–1324. Available from: https://doi.org/10.1111/bph.13625

Braakhuis AJ. Donaldson CI. Lim JC. Donaldson PJ. Nutritional strategies to prevent lens cataract: Current status and future strategies. Nutrients. 2019; 11(5). Available from: https://doi.org/10.3390/nu11051186

Buscemi S. Corleo D. Di Pace F. Petroni M. L. Satriano A. Marchesini G. The effect of lutein on eye and extra-eye health. Nutrients. 2018; 10(9): 1–24. Available from: https://doi.org/10.3390/nu10091321

Ishida H. Shibata T. Shibata S. Tanaka Y. Sasaki H. Kubo E. Lutein plus Water Chestnut (Trapa bispinosa Roxb.) Extract Inhibits the Development of Cataracts and Induces Antioxidant Gene Expression in Lens Epithelial Cells. BioMed Research International. 2020. Available from: https://doi.org/10.1155/2020/9204620

Fuad NIN. Sekar M. Gan SH. Lum PT. Vaijanathappa J. Ravi S. Lutein: A comprehensive review on its chemical, biological activities and therapeutic potentials. Pharmacognosy Journal. 2020; 12(6): 1769–1778. Available from: https://doi.org/10.5530/pj.2020.12.239

Padmanabha S. Vallikannan B. Fatty acids modulate the efficacy of lutein in cataract prevention: Assessment of oxidative and inflammatory parameters in rats. Biochemical and Biophysical Research Communications. 2018; 500(2): 435–442. Available from: https://doi.org/10.1016/j.bbrc.2018.04.098

How to Cite
Mariati, S., Bhekti, D. D., Sylvestris, A., & Prabawati, R. K. (2023). Potensi Ekstrak Jagung Sebagai Pencegahan Katarak . ARTERI : Jurnal Ilmu Kesehatan, 4(1), 14-20. https://doi.org/10.37148/arteri.v4i1.246

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